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KMID : 0043319970200050476
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Archives of Pharmacal Research
1997 Volume.20 No. 5 p.476 ~ p.479
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Studies on the Synthesis and in vitro anti-Tumor Activity of Dihydroberberine Derivatives
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Kim In-Jong
Park Yea-Jin
Kim Joo-Il
Lee Kyung-Tae
Kim Sin-Kyu
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Abstract
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Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell.
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KEYWORD
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Dihydroberberine, Dichlorocarbene addition, Antiproliperative activity
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